| Metformin compared to metformin combined with OCP for hirsutism, acne and menstrual pattern in adolescent women with PCOS |
|
Patient or population: adolescent women with PCOS
Setting: Hospital or University Clinics
Intervention: metformin
Comparison: metformin combined with OCP |
| Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect
(95% CI) |
No of participants
(studies) |
Quality of the evidence
(GRADE) |
Comments |
| Risk with metformin combined with OCP |
Risk with metformin |
| Hirsutism ‐ Clinical F‐G score |
|
No trials reported on outcome "Hirsutism ‐ Clinical F‐G score" |
| Adverse event ‐ Severe |
Gastro‐intestinal |
No trials reported on outcome "Adverse event ‐ Severe ‐ Gastro‐intestinal" |
| Others |
No trials reported on outcome "Adverse event ‐ Severe ‐ Others" |
| Adverse event ‐ Minor |
Gastro‐intestinal |
No trials reported on outcome "Adverse event ‐ Minor ‐ Gastro‐intestinal" |
| Others |
No trials reported on outcome "Adverse event ‐ Minor ‐ Others" |
| Improved menstrual pattern |
Shortening of inter menstrual day |
No trials reported on outcome "Improved menstrual pattern (i.e. shortening of intermenstrual days)" |
| An initiation of menses or cycle regularity |
No trials reported on outcome "Improved menstrual pattern (i.e. an initiation of menses or cycle regularity)" |
| Acne ‐ Visual analogue scale or Clinical acne score |
|
No trials reported either on outcome "Acne ‐ Visual analogue scale" or "Acne ‐ Clinical acne score" |
| BMI (kg/m2) |
|
No trials reported on outcome "BMI" |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
BMI: body mass index; CI: Confidence interval; F‐G: Ferriman‐Gallwey score; MD: Mean difference; OR: Odds ratio |
|
GRADE Working Group grades of evidence
High quality: further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: we are very uncertain about the estimate. |
