Comparison 6. Adult ‐ Metformin versus Metformin combined with OCP (Metabolic parameters).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Fasting insulin (mIU/L)	5	199	Mean Difference (IV, Fixed, 95% CI)	‐1.32 [‐2.63, ‐0.01]
6.1.1 BMI ≤ 25 kg/m2	2	74	Mean Difference (IV, Fixed, 95% CI)	‐1.58 [‐3.47, 0.32]
6.1.2 BMI > 25 kg/m2 < 30 kg/m2	3	125	Mean Difference (IV, Fixed, 95% CI)	‐1.09 [‐2.91, 0.72]
6.2 Fasting glucose (mmol/L)	4	170	Mean Difference (IV, Fixed, 95% CI)	‐0.21 [‐0.37, ‐0.06]
6.2.1 BMI ≤ 25 kg/m2	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.25 [‐0.54, 0.04]
6.2.2 BMI > 25 kg/m2 < 30 kg/m2	3	130	Mean Difference (IV, Fixed, 95% CI)	‐0.20 [‐0.38, ‐0.01]
6.3 Total Cholesterol (mmol/L)	5	216	Mean Difference (IV, Random, 95% CI)	‐0.54 [‐0.97, ‐0.11]
6.3.1 BMI ≤ 25 kg/m2	1	40	Mean Difference (IV, Random, 95% CI)	‐0.65 [‐1.56, 0.26]
6.3.2 BMI > 25 kg/m2 < 30 kg/m2	4	176	Mean Difference (IV, Random, 95% CI)	‐0.52 [‐1.02, ‐0.02]
6.4 HDL Cholesterol (mmol/L)	5	216	Mean Difference (IV, Fixed, 95% CI)	0.01 [‐0.08, 0.09]
6.4.1 BMI ≤ 25 kg/m2	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.64 [‐0.99, ‐0.29]
6.4.2 BMI > 25 kg/m2 < 30 kg/m2	4	176	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.04, 0.14]
6.5 LDL Cholesterol (mmol/L)	4	176	Mean Difference (IV, Fixed, 95% CI)	‐0.13 [‐0.32, 0.06]
6.5.1 BMI > 25 kg/m2 < 30 kg/m2	4	176	Mean Difference (IV, Fixed, 95% CI)	‐0.13 [‐0.32, 0.06]
6.6 Triglycerides (mmol/L)	5	216	Mean Difference (IV, Fixed, 95% CI)	‐0.22 [‐0.37, ‐0.07]
6.6.1 BMI ≤ 25 kg/m2	1	40	Mean Difference (IV, Fixed, 95% CI)	‐0.69 [‐1.14, ‐0.24]
6.6.2 BMI > 25 kg/m2 < 30 kg/m2	4	176	Mean Difference (IV, Fixed, 95% CI)	‐0.17 [‐0.32, ‐0.01]