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. 2020 Aug 13;2020(8):CD005552. doi: 10.1002/14651858.CD005552.pub3

Comparison 9. Adult ‐ OCP versus Metformin combined with OCP (Metabolic parameters).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
9.1 Fasting insulin (mIU/L) 12 602 Mean Difference (IV, Fixed, 95% CI) 2.29 [1.49, 3.09]
9.1.1 BMI ≤ 25 kg/m2 5 198 Mean Difference (IV, Fixed, 95% CI) 4.77 [3.26, 6.28]
9.1.2 BMI > 25 kg/m2 < 30 kg/m2 7 385 Mean Difference (IV, Fixed, 95% CI) 1.37 [0.42, 2.32]
9.1.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) ‐1.63 [‐9.67, 6.41]
9.2 Fasting glucose (mmol/L) 10 529 Mean Difference (IV, Fixed, 95% CI) 0.20 [0.11, 0.29]
9.2.1 BMI ≤ 25 kg/m2 5 205 Mean Difference (IV, Fixed, 95% CI) 0.11 [‐0.07, 0.29]
9.2.2 BMI > 25 kg/m2 < 30 kg/m2 4 305 Mean Difference (IV, Fixed, 95% CI) 0.25 [0.14, 0.36]
9.2.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) ‐0.30 [‐0.81, 0.21]
9.3 Total Cholesterol (mmol/L) 13 668 Mean Difference (IV, Fixed, 95% CI) 0.06 [‐0.05, 0.17]
9.3.1 BMI ≤ 25 kg/m2 4 176 Mean Difference (IV, Fixed, 95% CI) ‐0.02 [‐0.20, 0.16]
9.3.2 BMI > 25 kg/m2 < 30 kg/m2 8 473 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐0.04, 0.25]
9.3.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) 0.30 [‐0.31, 0.91]
9.4 HDL Cholesterol (mmol/L) 13 668 Mean Difference (IV, Fixed, 95% CI) 0.05 [0.01, 0.09]
9.4.1 BMI ≤ 25 kg/m2 4 176 Mean Difference (IV, Fixed, 95% CI) 0.05 [‐0.00, 0.10]
9.4.2 BMI > 25 kg/m2 < 30 kg/m2 8 473 Mean Difference (IV, Fixed, 95% CI) 0.04 [‐0.02, 0.11]
9.4.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐0.02, 0.42]
9.5 LDL Cholesterol (mmol/L) 13 668 Mean Difference (IV, Fixed, 95% CI) 0.04 [‐0.05, 0.14]
9.5.1 BMI ≤ 25 kg/m2 4 176 Mean Difference (IV, Fixed, 95% CI) 0.01 [‐0.18, 0.21]
9.5.2 BMI > 25 kg/m2 < 30 kg/m2 8 473 Mean Difference (IV, Fixed, 95% CI) 0.04 [‐0.07, 0.16]
9.5.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) 0.30 [‐0.27, 0.87]
9.6 Triglycerides (mmol/L) 13 668 Mean Difference (IV, Fixed, 95% CI) ‐0.02 [‐0.09, 0.04]
9.6.1 BMI ≤ 25 kg/m2 4 176 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.08, 0.11]
9.6.2 BMI > 25 kg/m2 < 30 kg/m2 8 473 Mean Difference (IV, Fixed, 95% CI) ‐0.06 [‐0.15, 0.03]
9.6.3 BMI ≥ 30 kg/m2 1 19 Mean Difference (IV, Fixed, 95% CI) 0.30 [‐0.67, 1.27]