Comparison 10. Adolescent ‐ Metformin versus OCP (Clinical parameters).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
10.1 Hirsutism ‐ Clinical F‐G score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10.1.1 BMI ≥ 30 kg/m2	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10.2 Hirsutism ‐ Subjective improvement	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.2.1 Mean BMI not stated	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.3 Adverse event ‐ severe	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.3.1 Others	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.4 Adverse event ‐ minor	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.4.1 Gastro‐intestinal	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.5 Improved menstrual pattern (ie. an initiation of menses or cycle regularity)	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.5.1 Mean BMI not stated	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10.6 Body Weight (kg)	2	111	Mean Difference (IV, Fixed, 95% CI)	‐18.77 [‐20.57, ‐16.98]
10.6.1 BMI ≥ 30 kg/m2	1	31	Mean Difference (IV, Fixed, 95% CI)	‐2.60 [‐17.87, 12.67]
10.6.2 Mean BMI not stated	1	80	Mean Difference (IV, Fixed, 95% CI)	‐19.00 [‐20.81, ‐17.19]
10.7 Body Mass Index (kg/m2)	3	69	Mean Difference (IV, Fixed, 95% CI)	‐1.45 [‐5.08, 2.17]
10.7.1 BMI ≥ 30 kg/m2	3	69	Mean Difference (IV, Fixed, 95% CI)	‐1.45 [‐5.08, 2.17]
10.8 Blood pressure ‐ systolic (mm Hg)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10.8.1 BMI ≥ 30 kg/m2	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10.9 Blood pressure ‐ diastolic (mm Hg)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
10.9.1 BMI ≥ 30 kg/m2	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected