Comparison 12. Adolescent ‐ Metformin versus OCP (Metabolic parameters).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
12.1 Fasting insulin (mIU/L)	2	53	Mean Difference (IV, Fixed, 95% CI)	4.55 [‐4.82, 13.92]
12.1.1 BMI ≥ 30 kg/m2	2	53	Mean Difference (IV, Fixed, 95% CI)	4.55 [‐4.82, 13.92]
12.2 Fasting glucose (mmol/L)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
12.2.1 BMI ≥ 30 kg/m2	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
12.3 Total Cholesterol (mmol/L)	2	47	Mean Difference (IV, Fixed, 95% CI)	‐1.12 [‐1.66, ‐0.58]
12.3.1 BMI ≥ 30 kg/m2	2	47	Mean Difference (IV, Fixed, 95% CI)	‐1.12 [‐1.66, ‐0.58]
12.4 HDL Cholesterol (mmol/L)	2	47	Mean Difference (IV, Fixed, 95% CI)	0.12 [‐0.10, 0.34]
12.4.1 BMI ≥ 30 kg/m2	2	47	Mean Difference (IV, Fixed, 95% CI)	0.12 [‐0.10, 0.34]
12.5 LDL Cholesterol (mmol/L)	2	47	Mean Difference (IV, Fixed, 95% CI)	‐0.92 [‐1.49, ‐0.35]
12.5.1 BMI ≥ 30 kg/m2	2	47	Mean Difference (IV, Fixed, 95% CI)	‐0.92 [‐1.49, ‐0.35]
12.6 Triglycerides (mmol/L)	3	69	Mean Difference (IV, Fixed, 95% CI)	‐0.13 [‐0.37, 0.10]
12.6.1 BMI ≥ 30 kg/m2	3	69	Mean Difference (IV, Fixed, 95% CI)	‐0.13 [‐0.37, 0.10]