Study	Reason for exclusion
Alpanes 2017	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Altinok 2018	No primary or secondary outcomes of interest for us.
Bachani 2016	Not a RCT
Bhattacharya 2012	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Bredella 2013	Not a RCT.
Burchall 2015	Not a RCT.
Cakiroglu 2013	Objective of the study was to look at outcomes according to the BMI and not per intervention. Email sent to the author asking for their results according to the treatment: no answer.
Diaz 2016	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Glintborg 2014b	Study excluded because population and results described in the first study of the same author.
Glintborg 2015	No primary or secondary outcomes of interest for us.
Glintborg 2017	Study excluded because population and results described in the first study of the same author.
Hadziomerovic‐Pekic 2010	No intervention of interest for us (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Harris‐Glocker 2009	No primary or secondary outcomes of interest for us.
Hu 2010	Not a RCT.
Hutchison 2008	Study excluded because population and results described in an other study. (Meyer 2007).
Ibanez 2010	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Ibanez 2017	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Kebapcilar 2010	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Kim 2010	Duration less than 3 months.
Ladson 2011	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Lazaro 2011	No intervention of interest (OCP versus Metformin or OCP versus Metformin + OCP or Metformin versus Metformin + OCP).
Lemay 2006	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Luque‐Ramirez 2008c	No primary or secondary outcomes of interest for us.
Luque‐Ramirez 2009	No primary or secondary outcomes of interest for us.
Luque‐Ramirez 2010a	No primary or secondary outcomes of interest for us.
Luque‐Ramirez 2011	No primary or secondary outcomes of interest for us.
Mehrabian 2016	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Mitkov 2005	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Moghtadaei 2009	Abstract only. No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Moretti 2016	Abstract only. No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
NCT02866786	Information given by the authors, no further publication.
Orbetzova 2011	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Panidis 2011	Not an RCT: quasi‐randomised study.
Pedersen 2018	Objective of the study was to look at outcomes per phenotype and not per intervention. Email sent to the author asking for their results according to the treatment: results presented in an another article by Glinborg.
Romualdi 2010	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).
Suvarna 2016	Not a RCT.
Teede 2010b	Study excluded because population and results described in another study.
Wang 2016	No intervention of interest (OCP versus metformin or OCP versus metformin + OCP or metformin versus metformin + OCP).

BMI: body mass index; OCP: oral contraceptive pill; RCT: randomised controlled trial.