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. Author manuscript; available in PMC: 2020 Aug 19.
Published in final edited form as: Mod Pathol. 2019 Aug 2;33(1):38–46. doi: 10.1038/s41379-019-0324-7

Fig. 1.

Fig. 1

Patterns of pan-Trk immunohistochemistry expression in NTRK fusion positive cancers. a Strong cytoplasmic and nuclear staining in this secretory carcinoma of the salivary gland with canonical ETV6-NTRK3 fusion. b Staining is occasionally weak and focal, seen in approximately 1% of tumor cells, as in this secretory carcinoma of the salivary gland. c Cytoplasmic staining is seen in this Lipofibromatosis-like Neural Tumor with a TPM3-NTRK1 fusion. d Cytoplasmic and perinuclear staining is seen in this colonic adenocarcinoma with a LMNA-NTRK1 fusion. e Cytoplasmic and nuclear staining is seen in this inflammatory myofibroblastic tumor with an ETV6-NTRK3 fusion. f Membranous staining is seen in this intrahepatic cholangiocarcinoma with a PLEKHA6-NTRK1 fusion