Table 1.

Identified Direct Host Factor Interactions with HEV

Factor	HEV binding partner	Biological functiona	Refs
ASGPR	neHEV virion	Attachment factor	[20]
C1-inhibitor (SERPING1)	ORF4	Altered complement activation or inhibitiona	[39]
C3	RdRp, HVR	Altered complement activation or inhibitiona	[39]
C4a	RdRp, HEL	Altered complement activation or inhibitiona	[39]
C8	RdRp, ORF4, HEL	Altered complement activation or inhibitiona	[39]
De-MARylation	X-domain (macro domain)	Immune evasiona	[67]
De-PARylation	X-domain (macro domain)	Immune evasiona	[67]
eEF1A1	RdRp, PCP, ORF4	Formation of a translation complexa, increased RdRp activity	[12,39]
eIF3A	RdRp, ORF4	Formation of a translation complexa	[39]
eIF4A2	RdRp, HVR	Formation of a translation complexa	[39]
Factor Xa	PCP	Processing of the ORF1 polyproteina	[38]
Ferritin	X-domain (macro domain)		[87]
hnRNPA2B1	Promoter regions in HEV RNA	Structural (re-)arrangementsa	[42]
hnRNPK	Promoter regions in HEV RNA	Structural (re-)arrangementsa	[42]
HSPGs	neHEV virion	Attachment factor	[16,22]
ISG15	MET-PCP	Invading cellular antiviral pathwaysa	[75]
ITGA3	neHEV virion	Entry receptora	[21]
Microtubules	ORF3	Cytoskeleton rearrangementa	[59,60]
PSMB1	X-domain (macro domain)	Altered processing of MHC-I complexesa	[39]
PSMB4	MET	Altered processing of MHC-I complexesa	[39]
RACK1	X-domain (macro domain)	Part of the viral replication/translation complex	[39]
Thrombin	X-domain (macro domain), RdRp	ORF1 polyprotein processinga	[38]
TIM-1	Phosphatidylserine on eHEV virion	Attachment factora	[16]
TSG101	ORF3	Loading of virions into MVBs	[61]
Ubiquitin	HVR, MET-PCP	Altered processing of MHC-I complexesa, invading cellular antiviral pathwaysa	[39,75]
Unknown glycosylase	ORF2	Production of immune decoysa	[47,58]
Unknown kinase	ORF3	Detecting virions ready for releasea	[57,58]
Unknown palmitoyltransferase	ORF3	Viral egress and subcellular localization	[63]
Unknown protease	ORF2	Production of immune decoysa	[47,58]

^aSpeculated.