Table III.
Comparison of diagnostic value among different microbiological tests, in which two sequencing failed patients had been excluded.
| Positive microbiological test | Prosthetic joint infection (n = 49) | Noninfection (n = 21) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Positive predictive value, % (95% CI) | Negative predictive value, % (95% CI) |
|---|---|---|---|---|---|---|
| Synovial fluid culture | 30 | 0 | 61.2 (47.2 to 73.6) | 100.0 (84.5 to 100.0) | 100.0 (88.6 to 100.0) | 52.5 (37.5 to 67.1) |
| Comprehensive culture | 39 | 1 | 79.6 (66.4 to 88.5) | 95.2 (77.3 to 99.2) | 97.5 (87.1 to 99.6) | 66.7 (48.8 to 80.8) |
| Synovial fluid mNGS | 47 | 1 | 95.9 (86.3 to 98.9) | 95.2 (77.3 to 99.2) | 97.9 (89.1 to 99.6) | 90.9 (72.2 to 97.5) |
| Synovial fluid culture or mNGS | 48 | 1 | 98.0 (89.3 to 99.6) | 95.2 (77.3 to 99.2) | 98.0 (89.3 to 99.6) | 95.2 (77.3 to 99.2) |
| Comprehensive culture or synovial fluid mNGS | 49 | 2 | 100.0 (92.7 to 100.0) | 90.5 (71.1 to 97.3) | 96.1 (86.8 to 98.9) | 100.0 (83.2 to 100.0) |
CI, confidence interval; mNGS, metagenomic next-generation sequencing