. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 Feb 12;29(4):871–879. doi: 10.1158/1055-9965.EPI-19-0644

Table 2.

Means, geometric means (GM), or proportions (%) and 95% confidence intervals of covariates by NMR and data source

	Slow metabolizers	Normal/fast metabolizers	p-value

PATH Wave 1
	N=4,642,172	N=13,941,182
Age (years), mean	40.23 (38.10, 42.37)	45.47 (43.97, 46.97)	0.0002
Female sex, %	40.79 (32.99, 49.09)	59.51 (55.20, 63.68)	<.0001
Body mass index, mean	27.82 (26.94, 28.70)	27.14 (26.54, 27.75)	0.1864
Years smoking, mean	21.92 (19.51, 24.34)	26.35 (25.16, 27.55)	0.0013
Smokes menthol cigarettes, %	27.13 (21.99, 32.97)	30.10 (24.54, 36.32)	0.4344
Urinary creatinine, GM	1.11 (1.00, 1.22)	0.88 (0.82, 0.94)	0.0004
HSI, mean	3.02 (2.80, 3.23)	3.27 (3.11, 3.44)	0.0510
HSI¹, mean	2.95 (2.73, 3.17)	3.28 (3.07, 3.48)	0.0178
WISDM PDM8, mean	3.30 (3.16, 3.43)	3.44 (3.35, 3.54)	0.0778
WISDM PDM8¹, mean	3.35 (3.22, 3.48)	3.43 (3.33, 3.53)	0.2884
Baseline data from RCT
	N=148	N=591

Age (years), mean	43.41 (41.27, 45.54)	45.36 (44.17, 46.54)	0.1392
Female sex, %	33.78 (26.15, 41.42)	47.88 (43.85, 51.92)	0.0020
Body mass index, mean	29.71 (28.69, 30.72)	28.50 (27.97, 29.01)	0.0376
Years smoking, mean	26.20 (24.06, 28.34)	28.23 (27.04, 29.41)	0.1245
Smokes menthol cigarettes, %	30.41 (22.98, 37.84)	23.35 (19.93, 26.77)	0.0754
Urinary creatinine, GM	1.00 (0.90, 1.12)	0.95 (0.90, 1.01)	0.4085
Expired CO, mean	20.08 (18.64, 21.51)	20.93 (20.12, 21.73)	0.3431
HSI, mean	3.42 (3.19, 3.65)	3.41 (3.29, 3.52)	0.9315
HSI¹, mean	3.34 (3.10, 3.57)	3.35 (3.21, 3.48)	0.9447
WISDM PDM16, mean	4.26 (4.04, 4.48)	4.23 (4.12, 4.35)	0.8415
WISDM PDM16¹, mean	4.27 (4.04, 4.50)	4.22 (4.08, 4.35)	0.6739

PATH data is weighted; Parentheses include 95% confidence intervals; GM: geometric mean

^1:

Estimates adjusted for age, sex, body mass index, duration regular smoking, and menthol use