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. 2020 Aug 17;8(2):e001113. doi: 10.1136/jitc-2020-001113

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Plasma exchange efficiently reduces total, programmed death-ligand 1 (PD-L1)-positive, and ADAM10-positive extracellular vesicle (EV) levels in vivo. Plasma levels of total EVs immediately prior to (pre) and after (post) therapeutic plasma exchange (TPE) are plotted. TPE significantly reduced (A) total (p<0.0001), (B) PD-L1-positive (p=0.028), and (C) ADAM10-positive (p<0.0001) but not (D) CD61-positive EVs (p=0.94) by Wilcoxon signed-rank test. See also online supplementary figures 5–7 and online supplementary table 4.