Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 17;8(2):e000207. doi: 10.1136/jitc-2019-000207

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

In vitro ICD induced by treatments and the effect on the antigen-presenting cells. (A) Flow cytometric quantification of calreticulin (CRT). (B) Extracellular adenosine triphosphate (ATP) level. (C) Flow cytometric analysis of dendritic cell (DC) maturation. (D) Fluorescent images of the exposed CRT on the C6 cell surface after treatments (scale bar: 10 µm). (E) M2 repolarization after treatments. (F and G) Activation of macrophages, as reflected by the biomarkers of CD80 and CD169. (H) Proportion of IFN-γ⁺ T cells primed with the matured DC cells that were activated by the drug-treated tumor cells. ATP, adenosine triphosphate; CDX-LIPO, CDX-modified liposomes; CRT, calreticulin; DC, dendritic cell; DSF/Cu, disulfiram/copper ion; HNK, honokiol; ICD, immunogeniccell death; IFN-γ, interferon gamma; LIPO, non-modified liposomes; mTOR, mammalian target of rapamycin.