TABLE 1.

Number of genes affected by TCS expression^a

Phospho-mimetic RR	No. of genes upregulated by fold change (P < 0.05)b		No. of genes downregulated by fold change (P < 0.05)b		% of genes regulated >|2|c	% of genes regulated >|4|c
	>2	>4	<−2	<−4
WalR	138	31	38	6	6.00	1.26
HptR	2	2	0	0	0.07	0.07
LytR	3	3	0	0	0.10	0.10
GraR	18	15	1	0	0.65	0.51
SaeR	74	53	33	2	3.65	1.87
TCS7	8	7	6	0	0.48	0.24
ArlR	34	20	59	19	3.17	1.33
SrrA	141	63	101	15	8.25	2.66
PhoP	237	64	149	48	13.16	3.82
AirR	96	50	54	3	5.11	1.81
VraR	63	21	24	2	2.97	0.78
AgrA	95	44	40	2	4.60	1.57
KdpE	224	87	103	17	11.15	3.54
HssR	138	52	64	2	6.88	1.84
NreC	154	55	82	8	8.04	2.15
BraR	127	23	137	16	9.00	1.33

^aThe expression of genes in the sample expressing the defined phosphomimetic response regulator (RR*) were analyzed, and differentially expressed genes were determined relative to the pRMC2 control sample.

^bThe columns showing the number of genes up- or downregulated by the expression of the indicated RR* using a fold change cutoff of at least >2-fold or >4-fold and a false discovery rate-corrected P value of <0.05.

^cThe columns showing percentages of genes regulated show the proportion of the S. aureus MW2 genome changing its expression at least two- or fourfold.