Skip to main content
. 2020 Aug 3;9:e54993. doi: 10.7554/eLife.54993

Figure 6. CHD4 is essential for a broad range of tumors.

(A and B) Violin and boxplots depicting CHD4 expression levels (data: r2.aml.nl) in normal (grey) and tumor tissue (orange). (C) Databases used to evaluate tumor sensitivities to CHD4 silencing or knockout. (D and E) Violin plots showing the tumor dependency scores, calculated by D2 or CERES, of the indicated NuRD members. CHD4 is displayed in orange. The -0.5 threshold is depicted as a dashed line.

Figure 6.

Figure 6—figure supplement 1. CHD4 depletion affects the viability of a variety of tumor types.

Figure 6—figure supplement 1.

(A and B) Boxplots demonstrate the sensitivity, displayed as dependency scores D2 or CERES, of the indicated tumor types to CHD4 knockdown (Combined RNAi) or knockout (CRISPR). (C and D) Violin plots show the cancer dependency scores, calculated by D2 or CERES, for the indicated SNF2-like family members of chromatin remodelers and BRD4. CHD4 is displayed in orange.