Appendix 1—figure 5. Comparing estimates of $N\mathbf{}\mathrm{(}t\mathrm{)}$ in humans.

Here, we show estimates of population size over time ($N(t)$) inferred using fourdifferent methods, smc+, and stairway plot, and MSMC with $n=2$ and $n=8$. Data were generated by simulating replicate human genomes under a constant sized population model with $N={10}^4$ and using the HapMapII_GRCh37 genetic map (Frazer et al., 2007). As a proxy for the ‘truth’, in black we show inverse coalescence rates as calculated from the demographic model used for simulation (see text).