Table 1:
Characteristics of the Study Participants in the Tennessee Colorectal Polyp Study and Biofilm Study
| Characteristic | No Polyp Controls | Hyperplastic Polyps | Adenomatous Polyps | Sessile Serrated Polyps | pheterogeneity | No Polyp Controls | Hyperplastic Polyps | Adenomatous Polyps | Sessile Serrated Polyps | pheterogeneity |
|---|---|---|---|---|---|---|---|---|---|---|
| Tennessee Colorectal Polyp Studya | Johns Hopkins Biofilm Studyb | |||||||||
| - | n=3258 | n=471 | n=1536 | n=181 | - | n=579 | n=63 | n=333 | n=96 | |
| Age (years; least square means) | 57.6 | 57.1 | 59.2e | 58.2 | <0.001 | 60.2 | 58.6 | 62.4e | 60.0 | <0.001 |
| Sex (% Female) | 45.4 | 36.5 e | 28.1e | 36.5 e | <0.001 | 59.6 | 55.1 | 47.7 e | 54.2 | 0.007 |
| Race (% Caucasian) | 91.8 | 91.7 | 89.9 | 93.3 | 0.10c | 88.6 | 91.6 | 90.5 | 96.1 | 0.10c |
| Study Site of (%) | ||||||||||
| VUMC | 76.1 | 68.2 e | 70.7 e | 74.6 | <0.001 | |||||
| VA-Nashville Campus | 23.9 | 31.8 | 29.3 | 25.4 | ||||||
| Educational Attainment (%) | ||||||||||
| High School or Less | 22.1 | 27.6 e | 28.0 e | 24.1 | <0.001c | |||||
| Some College | 27.6 | 28.0 | 27.8 | 26.1 | ||||||
| College Graduate | 22.2 | 23.1 | 21.7 | 27.9 | ||||||
| Graduate/Professional School | 28.1 | 21.3 | 22.5 | 21.9 | ||||||
| Employment Status (%) | ||||||||||
| Employed | 65.7 | 59.4 | 60.7 | 63.7 | 0.35c | |||||
| Disabled | 1.9 | 5.3e | 2.7 | 1.1 | ||||||
| Retired | 29.1 | 28.8 | 32.6e | 31.8 | ||||||
| Unemployed | 3.3 | 6.5 | 4.0 | 3.5 | ||||||
| Indication for Colonoscopy (%) | ||||||||||
| Average Risk Screening | 57.6 | 54.9 | 55.7 | 57.3 | 0.33c | 63.2 | 52.2 | 60.5 | 52.1 | 0.02c |
| Family History | 13.1 | 14.3 | 12.9 | 16.2 | ||||||
| Diagnostic/Follow Up | 21.1 | 20.3 | 22.8 | 14.6 | 13.4 | 15.1 | 7.8 e | 15.1 | ||
| Surveillance | - | - | - | - | 23.4 | 32.6 e | 31.7 e | 32.8 e | ||
| Other | 8.2 | 10.5 | 8.5 | 12.0 | - | - | - | - | ||
| Family History of Colorectal Cancer (%) | 9.0 | 8.8 | 9.6 | 11.4 | 0.04c | 18.8 | 23.8 | 19.3 | 13.7 | 0.40c |
| Regular Alcohol Intake (%) | ||||||||||
| Never | 60.4 | 54.2 e | 56.3 e | 56.5 | 0.02c | |||||
| Former | 20.0 | 22.3 | 23.0 | 19.4 | ||||||
| Current | 19.6 | 23.5 | 20.7 | 24.0 | ||||||
| Never | 48.6 | 56.7 | 49.4 | 45.7 | 0.08c | |||||
| < than 14 drinks/wk | 41.8 | 25.2 e | 41.7 | 41.8 | ||||||
| > than 14 drinks/wk | 9.6 | 18.1 e | 8.9 | 12.5 e | ||||||
| Cigarette Smoking Status (%) | ||||||||||
| Never | 54.7 | 32.0 e | 44.2 e | 37.0 e | <0.001c | 63.9 | 45.7 | 53.0 | 55.2 | <0.001c |
| Former | 34.7 | 40.3 | 32.8 | 34.3 | 28.6 | 41.8 | 30.5 | 28.9 | ||
| Current | 10.6 | 27.7 | 23.0 | 28.6 | 7.5 | 12.4 | 16.6 e | 15.9 e | ||
| Regular Physical Activity in the Past 10 Years (%)d | 58.8 | 51.3 e | 52.7 e | 53.0 | <0.001c | 79.8 | 74.4 | 76.2 | 81.9 | 0.57c |
| Current Use of NSAIDs (%) | 51.4 | 51.5 | 46.2 e | 48.1 | 0.009c | 27.4 | 38.2 | 29.3 | 27.0 | 0.38c |
| Body Mass Index (kg/m2; least square means) | 27.8 | 28.9 e | 28.5 e | 28.6 | <0.001c | 29.5 | 30.4 | 29.2 | 29.5 | 0.06c |
| Personal History of Colorectal Polyp (%) | ||||||||||
| Yes | 29.7 | 30.9 | 33.5 e | 32.2 e | 0.0002c | |||||
| No | 68.4 | 63.1 | 63.6 | 66.7 | ||||||
| Unknown | 2.0 | 6.0 | 2.9 | 1.1 | ||||||
| Personal History of Cholecystectomy (%) | 8.7 | 9.9 | 14.8 e | 19.8 e | 0.006c | |||||
| Red meat consumption (g/day, least square means) | 51.0 | 65.9 e | 62.4 e | 67.2 e | <0.001c | |||||
| Daily Energy Intake (kcal; least square means) | 2051 | 2033 e | 2163 e | 2178 | <0.001c | |||||
| Frequency of Dairy Intake Excluding Yogurt (%) | ||||||||||
| Never/Rarely | 1.7 | 1.3 | 3.0 e | 0.3 | 0.02c | |||||
| Monthly Less than Weekly | 5.0 | 5.8 | 5.7 | 4.9 | ||||||
| Weekly Less than Daily | 37.3 | 39.7 | 40.5 | 43.4 | ||||||
| Daily | 56.0 | 53.2 | 50.8 | 51.4 | ||||||
| Frequency of Yogurt Intake (%) | ||||||||||
| Never/Rarely | 48.5 | 53.7 e | 53.8 e | 56.0 | 0.002 c | 33.3 | 31.0 | 42.1 | 37.1 | 0.06c |
| Monthly Less than Weekly | 18.1 | 17.7 | 18.3 | 18.4 | ||||||
| Weekly Less than Daily | 25.9 | 24.2 | 21.8 | 22.0 | ||||||
| Daily | 7.4 | 4.4 | 6.2 | 3.6 | ||||||
| 1 or more/month | 21.0 | 22.5 | 21.3 | 26.8 | ||||||
| 1 or more/week | 45.6 | 46.5 | 36.6 e | 36.1 e | ||||||
| Daily Amount of Yogurt Intake (cups) | 0.13 | 0.10 e | 0.11 e | 0.09 e | 0.004 c | |||||
| Use of a Probiotic Supplement (%) | 20.5 | 21.1 | 13.8 e | 14.4 e | 0.04c | |||||
Data presented as least square mean of log transformed data (continuous) or frequencies standardized to age (5 year categories) and sex distribution of controls with exception of age, sex and study site, which are presented as n and percentages for categorical data and mean values and standard deviation for continuous data.
Data presented as least square mean of log transformed data (continuous) or frequencies standardized to age (5 year categories) and sex distribution of controls with exception of age and sex, which are presented as n and percentages for categorical data and mean values and standard deviation for continuous data.
P-values adjusted for age (5-year categories) and sex.
Current Moderate/Vigorous Physical Activity (%)
Case group least square mean or frequencies are significantly different from the control group.