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. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Circ Heart Fail. 2020 Jul 28;13(8):e007067. doi: 10.1161/CIRCHEARTFAILURE.120.007067

Figure 2. — Adjusted* restricted cubic spline models showing the association of GlycA levels with hazard ratio of (A) HF, (B) HFpEF, (C) HFrEF.

*Spline models adjusted for age, sex, and race/ethnicity, MESA site, education, health insurance, BMI, smoking status, pack-years of smoking, physical activity, systolic blood pressure, use of antihypertensive medication, total cholesterol, HDL- cholesterol, use of lipid-lowering medications, diabetes, eGFR, ln(CRP), ln(IL-6) and ln(Fibrinogen).

The 4 knots are at 5^th, 25^th, 65^th and 95^th percentiles. Black curves represent the HR for the type of HF by proportion of population with the respective GlycA concentration. The 95% CI is represented by the gray shadow.

Figure 2. — Adjusted* restricted cubic spline models showing the association of GlycA levels with hazard ratio of (A) HF, (B) HFpEF, (C) HFrEF.

*Spline models adjusted for age, sex, and race/ethnicity, MESA site, education, health insurance, BMI, smoking status, pack-years of smoking, physical activity, systolic blood pressure, use of antihypertensive medication, total cholesterol, HDL- cholesterol, use of lipid-lowering medications, diabetes, eGFR, ln(CRP), ln(IL-6) and ln(Fibrinogen).

The 4 knots are at 5^th, 25^th, 65^th and 95^th percentiles. Black curves represent the HR for the type of HF by proportion of population with the respective GlycA concentration. The 95% CI is represented by the gray shadow.