Table 4.

Full linear mixed model on the outcome composite Z-score

Fixed effect	Coefficient	Standard error	p value
Intercept	0.38381	0.66321	0.57
Age, in years	− 0.00065	0.01631	0.97
Use of neuropsychiatric medication	0.15100	0.33070	0.65
cART, in months	− 0.00378	0.00441	0.40
CD4 count, in cell/mm3	− 0.00008	0.00030	0.78
CD4 nadir, in cell/mm3	− 0.00010	0.00072	0.89
HIV disease duration, in months	0.00006	0.00345	0.99
EFV concentration, in mg/L*	− 0.07816	0.05470	0.17
Plasma NFL, in pg/mL	0.00117	0.00355	0.75
Time point in study**	0.26045	0.07457	< 0.01

*Efavirenz concentration transformed to log variable

**Time is defined as a categorical variable

cART combination antiretroviral therapy, HIV human immunodeficiency virus, NFL neurofilament light