Table 1.
Demographics
| Total (n=175) |
Pathogenic (n=31) |
Benign/Normal (n=144) |
p-value | |
|---|---|---|---|---|
| Age at dissection (years) | 55 (46, 65) | 43 (30, 51) | 56 (47, 66) | <0.0001 |
| Sex, male | 112 (64) | 14 (45) | 98 (68) | 0.02 |
| Body mass index (kg/m2) | 29 (25, 33) | 27 (24, 30) | 29 (25, 34) | 0.09 |
| Hypertension | 109 (62) | 8 (26) | 101 (70) | <0.0001 |
| Dyslipidemia | 50 (29) | 3 (10) | 47 (33) | 0.01 |
| Coronary artery disease | 16 (9) | 2 (7) | 14 (10) | 0.74 |
| Smoking history | 79 (45) | 10 (32) | 69 (48) | 0.11 |
| COPD | 9 (5) | 0 (0) | 9 (6) | 0.36 |
| Diabetes | 6 (3) | 0 (0) | 6 (4) | 0.59 |
| History of stroke | 2 (1) | 0 (0) | 2 (1) | 1.00 |
| Chronic kidney disease | 6 (3) | 0 (0) | 6 (4) | 0.59 |
| Peripheral arterial disease | 2 (1) | 0 (0) | 2 (1) | 1.00 |
| Prior cardiac surgery | 16 (9) | 6 (19) | 10 (7) | 0.04 |
| Root replacement | 8 (5) | 5 (16) | 3 (2) | 0.005 |
| Aortic aneurysm | ||||
| Root | 61 (35) | 17 (55) | 44 (31) | 0.01 |
| Ascending | 78 (45) | 14 (45) | 64 (44) | 0.94 |
| Arch | 32 (18) | 4 (13) | 28 (19) | 0.39 |
| Descending | 54 (31) | 7 (23) | 47 (33) | 0.27 |
| Aortic dissection | ||||
| Type A | 108 (62) | 21 (68) | 87 (60) | 0.45 |
| Type B | 67 (38) | 10 (32) | 57 (40) | 0.45 |
| Condition at time of dissection | ||||
| Acute stroke | 4 (2) | 2 (7) | 2 (1) | 0.15 |
| Acute myocardia infarction | 2 (1) | 1 (3) | 1 (1) | 0.32 |
| Acute renal failure | 6 (3) | 1 (3) | 5 (4) | 1.00 |
| Acute paralysis | 0 (0) | 0 (0) | 0 (0) | - |
| Medications at time of dissection | ||||
| Beta blocker | 46 (26) | 6 (19) | 40 (28) | 0.33 |
| ACE inhibitor | 23 (13) | 3 (10) | 20 (14) | 0.77 |
| Calcium channel blocker | 15 (9) | 0 (0) | 15 (10) | 0.08 |
| Angiotensin II receptor blocker | 6 (3) | 0 (0) | 6 (4) | 0.59 |
Data presented as median (25%, 75%) for continuous data and n (%) for categorical data.
ACE = angiotensin converting enzyme; COPD=chronic obstructive pulmonary disease