Table 3. Performance of transient elastography and non-invasive blood parameters in detecting significant liver fibrosis.

Parameter	Formula	n	AUROC	95%CI	p value	Best cut-off	PPV	NPV
Transient elastography	-	85	0.793	0.665, 0.921	0.004	5.35	19%	100%
APRI	$\frac{(\frac{AST}{ULN})\times 100}{Plt}$	95	0.723	0.557, 0.889	0.013	0.935	60%	93%
FIB-4	$\frac{Age\times AST}{Plt\times \surd ALT}$	95	0.764	0.608, 0.920	0.003	2.324	60%	93%
GPR	$\frac{(\frac{GGT}{ULN})\times 100}{Plt}$	79	0.757	0.605, 0.909	0.009	0.444	35%	95%
GAR	$\frac{GGT}{Albumin}$	78	0.734	0.551, 0.917	0.013	16.918	60%	93%

Abbreviations: APRI, aspartate aminotransferase-to-platelet ratio index; FIB-4, Fibrosis-4; GAR, gamma-glutamyl transpeptidase-to-albumin ratio; GPR, gamma-glutamyl transpeptidase-to-platelet ratio; NPV, negative predictive value; Plt, platelet; PPV, positive predictive value; ULN, upper limit of normal.