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Voluntary wheel running induces antidepressant-like effect in the socially isolated and grouped animals. The effect of physical activity on the immobility time in the TST (Panel A) and the crossings and rearings in the open field test (Panels B and C, respectively) of the socially isolated or grouped mice. *p < 0.05 and ⁎⁎p < 0.01 as compared to sedentary socially isolated mice (n = 9; two-way ANOVA followed by Newman-Keuls post-hoc test).
