Table 1.

Clinicopathological factors of triple-negative cancer (TNC) and the status of intratumoral CD4, CD8, and FOXP3 (N = 107)

Clinicopathological parameter	Total no. of cases	iCD4			iCD8			iFOXP3			iCD4/CD8			iCD8/FOXP3			iFOXP3/CD4
		Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*
Age (years)				0.908			0.925			0.752			0.503			0.778			0.916
< 60	52	28	24		26	26		29	23		27	25		26	26		27	25
≥ 60	55	29	26		28	27		29	26		25	30		26	29		28	27
Tumor size (cm)				0.034*			0.199			0.292			0.027*			0.850			0.025*
≤ 2	69	42	27		38	31		40	29		39	30		34	35		41	28
> 2	38	15	23		16	22		18	20		13	25		18	20		14	24
Histological grade				0.006*			0.880			0.073			0.093			0.191			0.083
I and II	31	23	8		16	15		21	10		19	12		12	19		20	11
III	76	34	42		38	38		37	39		33	43		40	36		35	41
Lymph node status				0.093			0.036*			0.496			0.876			0.033*			0.094
Absent	65	30	35		27	38		33	32		32	33		25	40		31	34
Present	30	21	9		21	9		19	11		15	15		19	11		20	10
N/A	12	6	6					6	6					8	4		4	8
iTILs				0.633			0.001*			0.003*			0.386			0.146			0.386
Low	54	30	24		36	18		37	17		24	30		30	24		30	24
High	53	27	26		18	35		21	32		28	25		22	31		25	28
sTILs				0.26			0.148			0.076			0.396			0.275			0.216
Low	58	28	30		33	25		36	22		26	32		31	27		33	25
High	49	29	20		21	28		22	27		26	23		21	28		22	27
Relapse-free survival				0.536			0.066			0.852			0.837			0.361			0.837
No recurrence	80	40	40		36	44		44	36		40	40		37	43		40	40
Recurrence	19	11	8		13	6		10	9		9	10		11	8		10	9
Overall survival				0.019*			0.059			0.129			0.059			0.466			0.07
Alive	87	41	46		40	47		45	42		40	47		41	46		41	46
Died	12	10	2		9	3		9	3		9	3		7	5		9	3

FOXP3 Forkhead box P3, TNC triple-negative cancer, N/A not applicable, i intratumoral, s stromal, TILs Tumor-infiltrating lymphocytes

*P value is significant

*χ2 test