Table 2.

Clinicopathological factors of triple-negative cancer (TNC) and the status of stromal CD4, CD8, and FOXP3 (N = 107)

Clinicopathological parameter	Total no. of cases	sCD4			sCD8			sFOXP3			sCD4/CD8			sCD8/FOXP3			sFOXP3/CD4
		Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*	Low	High	P value*
Age (years)				0.379			0.702			0.631			0.379			0.925
< 60	52	23	29		18	34		25	27		29	23		26	26		25	27	0.631
≥ 60	55	29	26		21	34		29	26		26	29		27	28		29	26
Tumor size (cm)				0.830			0.186			0.199			0.553			0.943			0.379
≤ 2	69	33	36		22	47		38	31		34	35		34	35		37	32
> 2	38	19	19		17	21		16	22		21	17		19	19		17	21
Histological grade				0.211			0.134			0.564			0.409			0.26			0.483
I and II	31	18	13		14	13		17	14		14	17		18	13		14	17
III	76	34	42		25	55		37	39		41	35		35	41		40	36
Lymph node status				0.089			0.05*			0.794			0.566			0.034*			0.789
Absent	65	37	28		18	47		34	31		36	29		26	39		33	32
Present	30	10	20		16	14		15	15		14	16		18	12		16	14
N/A	12	6	6		5	7		5	7		5	7		9	3		5	7
iTILs				0.770			0.597			0.772			0.925			0.628			0.922
Low	54	27	27		21	33		28	26		28	26		28	26		27	27
High	53	25	28		18	35		26	27		27	26		25	28		27	26
sTILs				0.942			0.249			0.066			0.752			0.916			0.622
Low	58	28	30		24	34		34	24		29	29		29	29		28	30
High	49	24	25		15	34		20	29		26	23		24	25		26	23
Relapse-free survival				0.013*			< 0.001*			< 0.001*			0.006*			< 0.001*			0.001*
No recurrence	80	42	38		23	57		48	32		45	35		32	48		48	32
Recurrence	19	4	15		14	5		2	17		4	15		19	0		3	16
Overall survival				0.331			0.004*			0.012*			0.232			0.003*			0.001*
Alive	87	42	45		28	59		48	39		45	42		40	47		50	37
Died	12	4	8		9	3		2	10		4	8		11	1		1	11

FOXP3 Forkhead box P3, TNC triple-negative cancer, N/A not applicable, i intratumoral, s stromal, TILs Tumor-infiltrating lymphocytes

*P value is significant

*χ2 test