Table 3.
The PRS effect on the risk of developing type 2 diabetes.
| Quintile | Sample size | Age, sex and BMI-adjusted model | Full model | ||
|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| 2 (20–40%) | 767 | 0.9 (0.6, 1.2) | 0.53 | 0.93 (0.6, 1.3) | 0.7 |
| 3 (40–60%) | 726 | 1.35 (1, 1.8) | 0.04 | 1.32 (0.96, 1.8) | 0.08 |
| 4 (60–80%) | 902 | 1.5 (1.1, 2) | 0.003 | 1.45 (1.07, 1.9) | 0.01 |
| 5 (> 80%) | 825 | 1.96 (1.4, 2.5) | 0.00001 | 1.72 (1.2, 2.3) | 0. 001 |
Hazard ratio (HR) with 95% confidence intervals (95% CI) from Cox regression analysis. The full model is adjusted for age, sex, BMI, fasting plasma glucose, 2-h plasma glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels. The first quintile (< 20%) containing 783 individuals were considered as reference. The whole sample size was 4,003 individuals.