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. 2020 Aug 20;11(8):663. doi: 10.1038/s41419-020-02907-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a CD44, CD133, EpCAM, and CD49f were compared between Nrf2-high and -low groups using the TCGA dataset. Ratios were calculated by dividing the mRNA expression of the Nrf2-high group by that of the Nrf2-low group. b Nrf2 expression was compared between HPV(+) and HPV(−) group using our own dataset (n = 100). Ratio was calculated by dividing the expression intensity of the HPV(+) group by that of the HPV(−) group. c CSCs expression compared between HPV(+) and HPV(−) group. Ratio was calculated by dividing the expression intensity of the HPV(+) group by that of the HPV(−) group. d Expression of CSCs was compared between Nrf2-high and Nrf2-low group. Ratios were calculated by dividing the expression intensity of the Nrf2-high group by that of the Nrf2-low group. e Cancer stem markers were compared between HNSCC and matched normal tissues. Ratio was calculated by dividing the mRNA expression of the tumor sample by that of the matched normal samples. In all cases, whiskers indicate the maximum and the minimum values. p-values were calculated using Student’s t test.