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. 2020 Aug 13;11:1790. doi: 10.3389/fimmu.2020.01790

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Copyright © 2020 Kim, Kim and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Process of the Immune response and metabolic reprogramming in Mtb- infected immune cells. After Mtb infection, inflammatory signaling is activated by TLR2 or 4. Also, Metabolism is switch to aerobic glycolysis mediated by HIF-1α which upregulates glycolytic enzymes. Increased glycolysis related to upregulate pro-inflammatory cytokines and anti-microbial effectors. PPARγ upregulates lipid synthetic gene for formation of lipid droplet which is exploited by Mtb for survival and growth. Blue, increased expression/level.