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. 2020 Aug 13;11:992. doi: 10.3389/fphar.2020.00992

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Copyright © 2020 Akone, Ntie-Kang, Stuhldreier, Ewonkem, Noah, Mouelle and Müller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modeling docking poses towards the homology model of showing the interaction of curcumin (2) and its two analogs (50–51) (A) and tetrahydrocurcumin (52, B) within the catalytic domain of DNMT1. The catalytic Cys1126, and anchoring Glu1668, Arg1312 are shown in the catalytic domain, (Reproduced with permission).