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. 2020 Jul 1;161(9):bqaa109. doi: 10.1210/endocr/bqaa109

Figure 1.

Figure 1.

Correlation of ESR1 mRNA and ERα protein levels in ER+ ILC and IDC tumors. A: ESR1 mRNA and RPPA ERα protein levels (B) in ER+ invasive lobular carcinoma (ILC) and ER+ invasive ductal carcinoma (IDC) samples analyzed from the TCGA data set. C:  PGR mRNA and PGR protein levels (D) from the TCGA data set. E: Correlation between RPPA ERα protein and ESR1 mRNA levels between ILC and IDC samples analyzed from the TCGA data set using Pearson’s (r) correlation. P = 5.9e-6 for Wilcoxon rank-sum test comparison of Pearson correlations. F:  ESR1 mRNA levels in IDC and ILC tumor samples as analyzed by qRT-PCR in the UPMC cohort. G: Immunohistochemical semiquantitation of ER in IDC and ILC tumor samples determined using a modified H-score. H:  PGR mRNA by qRT-PCR and immunohistochemical semiquantitation of PGR (I) in IDC and ILC tumor samples determined using a modified H-score in the UPMC cohort. J: Correlation between ER IHC H-score and ESR1 mRNA levels between ILC and IDC samples as analyzed using Pearson’s coefficient (r) correlation. P = 0.0017 for Wilcoxon rank-sum test comparison of Pearson correlations.