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. 2020 Aug 13;14:862. doi: 10.3389/fnins.2020.00862

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Copyright © 2020 Lim, Li, He, Vingrys, Chinnery, Mullen, Bui and Nguyen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-related changes in retinal function in 5xFAD mice. Grouped averaged waveforms are shown for (A) 6-month-old (B) 12-month-old (C) 17-month-old mice. Lower panels show the ganglion cell dominated STR response (−5.01 to −4.87 log cd⋅s/m²). Rod and mixed rod-cone response are elicited with increasing luminous energies. The uppermost panel reflects the cone response isolated using a twin-flash paradigm. STR, scotopic threshold response – ganglion cell dominant; pSTR, positive STR; nSTR, negative STR; a-wave – photoreceptoral response; b-wave – bipolar cell response; oscillatory potentials – amacrine cell dominant.