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. 2020 Aug 7;10:1245. doi: 10.3389/fonc.2020.01245

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Copyright © 2020 Lyu, Yao, Wang, Zheng, Xu, Wang, Zhang, Deng, Wu, Yang, Lyu, Guan and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of HLA-DPB2/HLA-DPB1 expression with immune infiltration level in BC. (A,B) Spearman correlation of immune infiltration level with HLA-DPB2 and HLA-DPB1 in BC and its subtype using TIMER database; (C) the heatmap of correlation between the abundance of tumor-infiltrating lymphocytes (TILs) and HLA-DPB1 expression in BC using TISIDB database; (D) the distribution of HLA-DPB1 expression across immune subtypes using TISIDB database, the statistical significance of differential expression evaluated using Kruskal–Wallis test. BC, breast cancer; C1 (wound healing); C2 (IFN-gamma dominant); C3 (inflammatory); C4 (lymphocyte depleted); C6 (TGF-b dominant).