. 2020 Aug 7;10:1245. doi: 10.3389/fonc.2020.01245

Table 1.

Correlation analysis between HLA-DPB2/HLA-DPB1 and biomarkers of immune cells in BC and its subtype (TIMER).

Description	Gene markers	HLA-DPB2								HLA-DPB1
		BRCA		BRCA-luminal		BRCA-Her2+		BRCA-basal		BRCA		BRCA-luminal		BRCA-Her2+		BRCA-basal
		Cor	P	Cor	P	Cor	P	Cor	P	Cor	P	Cor	P	Cor	P	Cor	P
B cell	CD19	0.411	9.90E-42^***	0.329	3.19E-15^***	0.500	6.56E-05^***	0.411	9.90E-42^***	0.463	7.30E-54^***	0.408	2.85E-23^***	0.552	7.14E-06^***	0.463	7.30E-54^***
	CD79A	0.408	3.88E-41^***	0.327	4.55E-15^***	0.513	3.83E-05^***	0.408	3.88E-41^***	0.467	4.47E-55^***	0.437	9.03E-27^***	0.530	1.91E-05^***	0.467	4.47E-55^***
Monocyte	CD86	0.425	6.45E-45^***	0.422	6.31E-25^***	0.383	3.02E-03^*	0.425	6.45E-45^***	0.655	4.57E-123^***	0.676	3.89E-74^***	0.610	3.66E-07^***	0.655	4.57E-123^***
	CD115 (CSF1R)	0.372	5.65E-34^***	0.368	5.85E-19^***	0.359	5.60E-03^*	0.372	5.65E-34^***	0.664	2.63E-127^***	0.692	8.82E-79^***	0.550	7.66E-06^***	0.664	2.63E-127^***
M1 Macrophage	INOS (NOS2)	0.046	1.43E-01	0.010	8.10E-01	0.037	7.83E-01	0.046	1.43E-01	0.058	6.73E-02	0.057	1.84E-01	0.152	2.56E-01	0.058	6.73E-02
	IRF5	0.288	1.76E-20^***	0.223	1.39E-07^***	0.401	1.80E-03^*	0.288	1.76E-20^***	0.383	4.14E-36^***	0.300	7.80E-13^***	0.526	2.24E-05^***	0.383	4.14E-36^***
	COX2(PTGS2)	0.082	9.29E-03^*	0.039	3.65E-01	0.089	5.06E-01	0.082	9.29E-03^*	0.035	2.69E-01	0.123	4.01E-03^*	–0.044	7.41E-01	0.035	2.69E-01
M2 Macrophage	CD163	0.228	3.72E-13^***	0.215	4.21E-07^***	0.299	2.24E-02	0.228	3.72E-13^***	0.438	9.42E-48^***	0.455	3.09E-29^***	0.387	2.72E-03^*	0.438	9.42E-48^***
	VSIG4	0.181	8.85E-09^***	0.188	9.42E-06^***	0.246	6.27E-02	0.181	8.85E-09^***	0.420	8.26E-44^***	0.446	5.04E-28^***	0.188	1.56E-01	0.420	8.26E-44^***
	MS4A4A	0.324	1.11E-25^***	0.332	1.68E-15^***	0.393	2.28E-03^*	0.324	1.11E-25^***	0.552	2.96E-80^***	0.536	7.42E-42^***	0.544	1.02E-05^***	0.552	2.96E-80^***
Neutrophils	CD66b (CEACAM8)	0.064	4.28E-02	0.026	5.49E-01	0.050	7.11E-01	0.064	4.28E-02	0.025	4.30E-01	0.017	7.01E-01	–0.063	6.39E-01	0.025	4.30E-01
	CD11b (ITGAM)	0.332	6.09E-27^***	0.320	1.81E-14^***	0.352	6.79E-03^*	0.332	6.09E-27^***	0.532	1.33E-73^***	0.544	2.16E-43^***	0.493	8.45E-05^***	0.532	1.33E-73^***
	CCR7	0.437	1.04E-47^***	0.384	1.33E-20^***	0.508	4.61E-05^***	0.437	1.04E-47^***	0.543	3.04E-77^***	0.487	9.79E-34^***	0.630	1.19E-07^***	0.543	3.04E-77^***
Natural killer cell	KIR2DL1	0.217	4.33E-12^***	0.215	4.26E-07^***	0.374	3.82E-03^*	0.217	4.33E-12^***	0.304	1.07E-22^***	0.299	1.04E-12^***	0.483	1.24E-04^**	0.304	1.07E-22^***
	KIR2DL3	0.248	2.20E-15^***	0.224	1.34E-07^***	0.435	6.40E-04^**	0.248	2.20E-15^***	0.319	5.25E-25^***	0.302	6.00E-13^***	0.492	8.62E-05^***	0.319	5.25E-25^***
	KIR2DL4	0.312	6.34E-24^***	0.271	1.31E-10^***	0.468	2.10E-04^**	0.312	6.34E-24^***	0.350	5.19E-30^***	0.321	1.74E-14^***	0.610	3.75E-07^***	0.350	5.19E-30^***
	KIR3DL1	0.233	9.08E-14^***	0.189	9.17E-06^***	0.355	6.28E-03^*	0.233	9.08E-14^***	0.315	2.31E-24^***	0.267	2.29E-10^***	0.295	2.48E-02	0.315	2.31E-24^***
	KIR3DL2	0.356	3.94E-31^***	0.291	4.54E-12^***	0.482	1.27E-04^**	0.356	3.94E-31^***	0.393	4.73E-38^***	0.388	5.42E-21^***	0.572	2.72E-06^***	0.393	4.73E-38^***
	KIR3DL3	0.195	6.10E-10^***	0.134	1.72E-03^*	0.333	1.07E-02	0.195	6.10E-10^***	0.214	9.17E-12^***	0.167	8.99E-05^***	0.497	7.22E-05^***	0.214	9.17E-12^***
	KIR2DS4	0.208	3.78E-11^***	0.167	9.17E-05^***	0.431	7.31E-04^**	0.208	3.78E-11^***	0.260	8.06E-17^***	0.225	1.08E-07^***	0.495	7.77E-05^***	0.260	8.06E-17^***
Dendritic cell	HLA-DPB1	0.570	8.08E-87^***	0.538	3.80E-42^***	0.616	2.68E-07^***	0.570	8.08E-87^***	−1.000	0.00E+00^***	−1.000	NA^***	−1.000	0.00E+00^***	−1.000	0.00E+00^***
	HLA-DQB1	0.443	5.27E-49^***	0.381	2.96E-20^***	0.443	4.92E-04^**	0.443	5.27E-49^***	0.703	3.74E-149^***	0.676	5.39E-74^***	0.591	1.05E-06^***	0.703	3.74E-149^***
	HLA-DRA	0.598	1.67E-97^***	0.592	8.09E-53^***	0.680	4.20E-09^***	0.598	1.67E-97^***	0.886	0.00E+00^***	0.908	4.98E-207^***	0.903	3.30E-22^***	0.886	0.00E+00^***
	HLA-DPA1	0.528	2.46E-72^***	0.533	2.55E-41^***	0.638	7.18E-08^***	0.528	2.46E-72^***	0.903	0.00E+00^***	0.921	7.33E-224^***	0.895	2.43E-21^***	0.903	0.00E+00^***
	BDCA-1 (CD1C)	0.365	9.02E-33^***	0.332	1.84E-15^***	0.356	6.02E-03^*	0.365	9.02E-33^***	0.485	1.07E-59^***	0.466	1.09E-30^***	0.354	6.44E-03^*	0.485	1.07E-59^***
	BDCA-4 (NRP1)	0.006	8.48E-01	0.038	3.80E-01	0.035	7.92E-01	0.006	8.48E-01	0.089	5.12E-03^*	0.173	5.00E-05^***	0.126	3.45E-01	0.089	5.12E-03*
	CD11c (ITGAX)	0.437	1.13E-47^***	0.416	3.41E-24^***	0.499	6.70E-05^***	0.437	1.13E-47^***	0.643	3.48E-117^***	0.650	1.24E-66^***	0.586	1.35E-06^***	0.643	3.48E-117^***
T cell	CD3D	0.552	2.04E-80^***	0.496	4.15E-35^***	0.620	2.09E-07^***	0.552	2.04E-80^***	0.734	1.20E-168^***	0.697	1.31E-80^***	0.793	1.13E-13^***	0.734	1.20E-168^***
	CD3E	0.536	5.41E-75^***	0.489	4.56E-34^***	0.596	8.07E-07^***	0.536	5.41E-75^***	0.704	1.21E-149^***	0.679	8.46E-75^***	0.792	1.38E-13^***	0.704	1.21E-149^***
	CD2	0.527	5.48E-72^***	0.484	2.44E-33^***	0.590	1.07E-06^**	0.527	5.48E-72^***	0.699	1.02E-146^***	0.677	3.52E-74^***	0.800	4.98E-14^***	0.699	1.02E-146^***
CD8+ T cell	CD8A	0.477	1.36E-57^***	0.437	7.54E-27^***	0.545	9.60E-06^***	0.477	1.36E-57^***	0.612	3.48E-103^***	0.590	1.63E-52^***	0.714	3.22E-10^***	0.612	3.48E-103^***
	CD8B	0.480	2.08E-58^***	0.459	1.04E-29^***	0.534	1.60E-05^***	0.480	2.08E-58^***	0.567	1.18E-85^***	0.596	9.73E-54^***	0.723	1.52E-10^***	0.567	1.18E-85^***
Th1	STAT1	0.240	1.75E-14^***	0.205	1.32E-06^***	0.210	1.13E-01	0.240	1.75E-14^***	0.262	4.08E-17^***	0.294	2.67E-12^***	0.397	2.05E-03^*	0.262	4.08E-17^***
	STAT4	0.430	4.13E-46^***	0.381	2.71E-20^***	0.494	8.15E-05^**	0.430	4.13E-46^***	0.551	5.98E-80^***	0.492	1.42E-34^***	0.765	2.87E-12^***	0.551	5.98E-80^***
	TNF-α (TNF)	0.225	7.76E-13^***	0.162	1.46E-04^**	0.273	3.82E-02	0.225	7.76E-13^***	0.259	9.27E-17^***	0.272	1.15E-10^***	0.314	1.64E-02	0.259	9.27E-17^***
	IFN-γ (IFNG)	0.433	1.31E-46^***	0.409	2.02E-23^***	0.589	1.16E-06^***	0.433	1.31E-46^***	0.544	1.61E-77^***	0.554	3.21E-45^***	0.651	3.25E-08^***	0.544	1.61E-77^***
	T-bet (TBX21)	0.516	9.75E-69^***	0.457	1.68E-29^***	0.589	1.17E-06^***	0.516	9.75E-69^***	0.683	1.49E-137^***	0.625	2.22E-60^***	0.762	3.54E-12^***	0.683	1.49E-137^***
Th2	GATA3	−0.203	1.05E-10^***	–0.140	1.03E-03^*	–0.085	5.27E-01	−0.203	1.05E-10^***	−0.129	4.82E-05^***	−0.209	8.83E-07^***	0.053	6.92E-01	−0.129	4.82E-05^***
	STAT6	0.086	6.52E-03^*	0.056	1.91E-01	0.044	7.43E-01	0.086	6.52E-03^*	0.159	4.33E-07^***	0.078	6.89E-02	0.112	4.03E-01	0.159	4.33E-07^***
	STAT5A	0.205	7.36E-11^***	0.161	1.57E-04^**	0.401	1.79E-03^*	0.205	7.36E-11^***	0.308	2.89E-23^***	0.330	2.64E-15^***	0.518	3.09E-05^***	0.308	2.89E-23^***
	IL13	0.167	1.25E-07^***	0.107	1.26E-02	0.393	2.28E-03^*	0.167	1.25E-07^***	0.200	2.05E-10^***	0.167	9.04E-05^***	0.349	7.31E-03^*	0.200	2.05E-10^***
Tfh	BCL6	–0.025	4.39E-01	–0.020	6.34E-01	–0.199	1.34E-01	–0.025	4.39E-01	0.045	1.54E-01	0.036	3.97E-01	–0.279	3.38E-02	0.045	1.54E-01
	IL21	0.307	4.20E-23^***	0.269	1.60E-10^***	0.434	6.72E-04^**	0.307	4.20E-23^***	0.306	5.26E-23^***	0.300	9.26E-13^***	0.362	5.25E-03^*	0.306	5.26E-23^***
Th17	STAT3	–0.059	6.17E-02	–0.022	6.00E-01	0.172	1.96E-01	–0.059	6.17E-02	–0.052	9.99E-02	–0.006	8.81E-01	–0.027	8.42E-01	–0.052	9.99E-02
	IL17A	0.147	3.22E-06^***	0.090	3.60E-02	0.091	4.99E-01	0.147	3.22E-06^***	0.145	4.11E-06^***	0.069	1.06E-01	0.118	3.78E-01	0.145	4.11E-06^***
Treg	FOXP3	0.433	1.09E-46^***	0.387	5.87E-21^***	0.589	1.12E-06^***	0.433	1.09E-46^***	0.530	3.42E-73^***	0.601	7.84E-55^***	0.707	5.62E-10^***	0.530	3.42E-73^***
	CCR8	0.323	1.22E-25^***	0.335	8.55E-16^***	0.269	4.11E-02	0.323	1.22E-25^***	0.377	5.91E-35^***	0.465	1.26E-30^***	0.398	1.97E-03^*	0.377	5.91E-35^***
	STAT5B	–0.019	5.48E-01	0.010	8.10E-01	0.349	7.24E-03^*	–0.019	5.48E-01	0.016	6.22E-01	0.055	2.01E-01	0.268	4.24E-02	0.016	6.22E-01
	TGFβ (TGFB1)	0.226	4.98E-13^***	0.176	3.48E-05^***	0.119	3.72E-01	0.226	4.98E-13^***	0.444	2.52E-49^***	0.379	4.87E-20^***	0.286	2.98E-02	0.444	2.52E-49^***
T cell exhaustion	PD-1 (PDCD1)	0.532	7.13E-74^***	0.489	4.59E-34^***	0.542	1.11E-05^***	0.532	7.13E-74^***	0.648	2.41E-119^***	0.599	2.54E-54^***	0.801	4.64E-14^***	0.648	2.41E-119^***
	CTLA4	0.479	3.42E-58^***	0.419	1.50E-24^***	0.585	1.45E-06^***	0.479	3.42E-58^***	0.555	2.69E-81^***	0.523	1.64E-39^***	0.744	2.25E-11^***	0.555	2.69E-81^***
	TIM-3 (HAVCR2)	0.387	6.57E-37^***	0.396	6.02E-22^***	0.407	1.53E-03^*	0.387	6.57E-37^***	0.632	3.62E-112^***	0.642	1.48E-64^***	0.572	2.76E-06^***	0.632	3.62E-112^***
	LAG3	0.400	2.08E-39^***	0.368	5.88E-19^***	0.404	1.68E-03^*	0.400	2.08E-39^***	0.484	1.56E-59^***	0.436	1.15E-26^***	0.652	3.05E-08^***	0.484	1.56E-59^***
	GZMB	0.417	5.47E-43^***	0.374	1.50E-19^***	0.520	2.82E-05^***	0.417	5.47E-43^***	0.528	2.35E-72^***	0.511	1.49E-37^***	0.715	2.87E-10^***	0.528	2.35E-72^***
TAM	CCL2	0.248	2.06E-15^***	0.204	1.52E-06^***	0.190	1.53E-01	0.248	2.06E-15^***	0.354	9.25E-31^***	0.364	1.48E-18^***	0.306	1.93E-02	0.354	9.25E-31^***
	CD68	0.339	3.24E-28^***	0.346	9.13E-17^***	0.367	4.59E-03^*	0.339	3.24E-28^***	0.584	5.26E-92^***	0.610	6.43E-57^***	0.450	3.97E-04^**	0.584	5.26E-92^***
	IL10	0.283	9.30E-20^***	0.250	3.31E-09^***	0.363	5.11E-03^*	0.283	9.30E-20^***	0.432	2.29E-46^***	0.412	1.06E-23^***	0.515	3.55E-05^***	0.432	2.29E-46^***

P < 0.01,

^**

P < 0.001,

^***

P < 0.0001.

Cor, correlation adjusted by purity; PD-1, programmed cell death protein 1; BRCA, invasive breast carcinoma.

The bold values indicate that the results are statistically significant.