Table 2A.

Immunhistochemical markers.

	All patients		M0 patients		M1 patients		p = 0
Marker	Nr of patients	Nr positiv(%)	Nr of patients	Nr positiv(%)	Nr of patients	Nr positiv(%)
CD56	89	87 (98%)	45	45 (100%)	44	42 (96%)	0.99
Chromogranin A	57	36 (63%)	27	19 (70%)	30	17 (57%)	0.28
Synaptophysin	79	63 (80%)	37	33 (89%)	42	30 (71%)	0.06
TTF1	71	64 (90%)	41	37(90%)	30	27 (90%)	0.97
Hif-1-alpha	44	44 (100)	29	29 (100%)	15	15 (100%)	n.a.
CD 44	44	44 (100)	29	29 (100%)	15	15 (100%)	n.a.
GLUT-1	36	43 (84%)	28	25 (89%)	15	11 (73%)	0.19
PD-1,	18	13 (72%)	12	11 (92%)	6	2 (33%)	0.02
PD-L1 tumor	19	2 (10%)	13	2 (15%)	6	0 (0%)	0.80
PD-L1 stroma	19	6 (32%)	13	5 (38%)	6	1 (17%)	0.36
PD-L1 macrophages	19	12 (63%)	13	10 (76%)	6	2 (33%)	0.08
MIB-1	34	n.a.	12	n.a.	22	n.a.	0.86

n.a., not applicable.