Table 4.

Multivariate analysis of different parameters concerning overall survival.

Variable	Hazard Ratio (95% CI)	p
LDH*	1.001 (0.999–1.004)	0.374
NSE*	1.002 (0.999–1.005)	0.273
Synaptophysin	0.914 (0.479–1.743)	0.785
PCI	0.477 (0.265–0.860)	0.014
M1	0.540 (0.258–1.129)	0.102
Cisplatin based doublets	0.555 (0.307–1.002)	0.051
Thoracic radiotherapy	0.532 (0.276–1.025)	0.059

^*Continuous variable.

PCI, prophylactic cranial irradiation; NSE, neuron specific enolase; LDH, lactate dehydrogenase.