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. 2020 Jul 29;8:580. doi: 10.3389/fcell.2020.00580

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Copyright © 2020 Dai, Xiao, Zhao, Chen, Liao and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone morphogenetic protein 2 (BMP2)-induced H19 expression is positively correlated with terminal chondrogenic differentiation markers. The correlations between BMP2-induced H19 expression and Sox9 messenger RNA (mRNA), collagen 2α1 mRNA, and Aggrecan mRNA were analyzed from day 1 to 5 and day 7 to 12, respectively, with Spearman’s correlation coefficients, r means correlation coefficients. (A) During the early stage of BMP2’s stimulation (days 1–5) Sox9 (r = 0.85, p < 0.01) (a) and Aggrecan (r = 0.63, p = 0.03) (c) expression levels were positively corelated with H19 expression level; however, Col2α (r = 0.19, p = 0.55) (b) expression levels were not significantly correlated with H19 expression levels. (B) In the late stage of BMP2’s stimulation (days 7–12) Sox9 mRNA (r = 0.71, p = 0.03) (a), Col2α mRNA (r = 0.92, p < 0.01) (b), and Aggrecan mRNA (r = 0.91, p < 0.01) (c) expression levels were positively corelated with H19 expression levels. Each assay was done in triplicate and/or carried out in three independent experiments at least; mean value of each independent experiment was shown.