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. 2020 Aug 4;12:240. doi: 10.3389/fnagi.2020.00240

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Copyright © 2020 Qin, An, Xu, Qi, Wang, Chen, Chen and Sha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of E2 on the proliferation of neural stem cells (NSCs) and the survival of immature neurons in the DG of APP/PS1 mice. (A,B) Bar graphs showing the numbers of BrdU⁺ cells in APP/PS1 mice or WT mice that were sham-operated (sham-op; open bars) or OVX (black bars). *P < 0.05 vs. age-matched sham-op APP/PS1 mice; ^#P < 0.05 and ^##P < 0.01 vs. age-matched OVX-APP/PS1 mice (two-way ANOVA). (C,D) The mean density of DCX⁺ cells in APP/PS1 mice or WT mice. *P < 0.05 and **P < 0.01 vs. age-matched sham-op mic; ^#P < 0.05 vs. 6-month-old OVX-APP/PS1 mice (two-way ANOVA).