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. 2020 Aug 4;12:240. doi: 10.3389/fnagi.2020.00240

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Copyright © 2020 Qin, An, Xu, Qi, Wang, Chen, Chen and Sha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-related increase in Aβ accumulation and the influence of E2 on Aβ formation in the hippocampus of APP/PS1 mice. (A,B) Bar graphs showing the level of total Aβ_1–42 or Aβ_1–40in APP/PS1 mice that were sham-op (open bars) or OVX (black bars). *P < 0.05 vs. 6-month-old sham-op APP/PS1 mice; ^#P < 0.05 vs. 6-month-old OVX-APP/PS1 mice (two-way ANOVA). (C) Representative images showing Aβ immunostaining in 6-month-old, 8-month-old, and 10-month-old APP/PS1 mice that were sham-op or OVX with vehicle or E2 treatment in the early period (E-E2), mid period (M-E2), or late period (L-E2). The data show the mean counts of Aβ deposits in the hippocampus of APP/PS1 mice. Scale bar = 200 μm.