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. 2020 Aug 4;12:240. doi: 10.3389/fnagi.2020.00240

Figure 6.

Figure 6

The administration of E2 in the early period post-OVX rescues the impaired telomerase activity in the DG in aged APP/PS1 mice. (A) Representative RT-polymerase chain reaction (PCR) analysis showing mRNA levels of TERT in 10-month-old APP/PS1 mice that were sham-op or OVX with vehicle or E2 treatment in the early period (E-E2), mid period (M-E2), or late period (L-E2). The bar graphs show the mRNA percentage level of TERT. **P < 0.01 vs. WT mice; #P < 0.05 and ##P < 0.01 vs. sham-op APP/PS1 mice; +P < 0.05 vs. OVX-APP/PS1 mice (two-way ANOVA). (B) Bar graphs showing the quantification of telomerase activity by telomeric repeat amplification protocol (TRAP; ΔFL/ΔR). **P < 0.01 vs. WT mice; #P < 0.05 and ##P < 0.01 vs. sham-op APP/PS1 mice; +P < 0.05 vs. OVX-APP/PS1 mice (two-way ANOVA).