Skip to main content
. 2020 Aug 4;12:240. doi: 10.3389/fnagi.2020.00240

Figure 7.

Figure 7

The administration of E2 in the early period post-OVX alleviates the cognitive deficits in aged APP/PS1 mice. (A,B) Influence of E2 treatment in the early period (E-E2), mid period (M-E2), or late period (L-E2) on working memory as assessed by the Y-maze test in 10-month-old APP/PS1 mice. The bar graphs show the spontaneous alternation ratio (%) and the total number of arm entries in the Y-maze test of APP/PS1 mice. **P < 0.01 vs. WT mice; #P < 0.05 and ##P < 0.01 vs. sham-op APP/PS1 mice; ++P < 0.01 vs. OVX-APP/PS1 mice (two-way ANOVA). (C) Spatial learning and memory were assessed by the Morris water maze (MWM). Each point represents the mean latency (sec) to reach the platforms (upper panel) and the swimming speeds (m/s; bottom panel). **P < 0.01 vs. WT mice; #P < 0.05 and ##P < 0.01 vs. sham-op APP/PS1 mice; +P < 0.05 vs. OVX-APP/PS1 mice (repeated measure ANOVA). (D) Probe trial test. The bars represent the percentages of swimming time spent in the platform quadrant. **P < 0.01 vs. WT mice; #P < 0.05 and ##P < 0.01 vs. sham-op APP/PS1 mice; +P < 0.05 vs. OVX-APP/PS1 mice (two-way ANOVA).