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. 2020 Aug 10;11:1620. doi: 10.3389/fimmu.2020.01620

Figure 1.

Figure 1

Profile of cyclin D1 (CCND1) amplification and association with prognosis. (A) Distribution of the top 10 cancer types with the frequency of CCND1 amplification in The Cancer Genome Atlas (TCGA) (n = 10,606), Memorial Sloan Kettering Cancer Center (MSKCC) (n = 10,109), and Geneplus (n = 6,536) databases. Cancers were sorted according to the frequency of CCND1 amplification. (B) The gene expression profile of CCND1 between the amplification group and the neutral group in the TCGA pan-cancer cohort (n = 2,633). The white dot represents the median value. The bottom and top of the violins are the 25th and 75th percentiles (interquartile range). Differences between the two groups were evaluated by unpaired t-tests. ns P ≥ 0.05; *P < 0.05; **P < 1 × 10−2; ***P < 1 × 10−3; ****P < 1 × 10−4. (C) Kaplan–Meier survival analysis of overall survival (OS) comparing the CCND1 amplification and neutral groups in patients in the TCGA pan-cancer cohort (n = 2,633). (D) Kaplan–Meier survival analysis of OS comparing the CCND1 amplification and neutral groups in patients in the MSKCC pan-cancer cohort (n = 3,629).