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. 2020 Aug 10;11:1620. doi: 10.3389/fimmu.2020.01620

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Copyright © 2020 Chen, Huang, Gao, Li, Lin, Chen, Chang, Chen, Guan, Pan, Xia, Guo, Pan, Xu, Yi and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of cyclin D1 (CCND1) amplification with prognosis in the Memorial Sloan Kettering Cancer Center (MSKCC)-IO cohort. (A) Kaplan–Meier survival analysis of overall survival (OS) comparing the CCND1 amplification and neutral groups in patients with melanoma treated with immune checkpoint inhibitors (ICIs) from the Robert, Allen, Snyder, and David cohorts (n = 464). (B) Kaplan–Meier survival analysis of OS comparing the CCND1 amplification and neutral groups in patients with solid tumors treated with ICIs in the MSKCC-IO pan-cancer cohort (n = 1,105). (C) Hazard ratios of CCND1 status across patients with different levels of tumor mutational burden (TMB) in the MSKCC-IO pan-cancer cohort (n = 1,105). (D) Kaplan–Meier survival analysis of OS comparing the CCND1 amplification and neutral groups in patients with solid tumors treated with ICIs identified with top 20% TMB within each histology in the MSKCC-IO cohort (n = 268).