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. 2020 Aug 10;11:1620. doi: 10.3389/fimmu.2020.01620

Figure 4.

Figure 4

Identification of hallmarks associated with cyclin D1 (CCND1) amplification in The Cancer Genome Atlas (TCGA) pan-cancer cohort (n = 2,633). (A) Different upregulation of inflammatory pathways among the CCND1 amplification group and the CCND1 neutral group in the TCGA pan-cancer cohort. The result is expressed according to the normalized enrichment score (NES). (B) The box and whiskers plots depict differences in transcript-level changes of transforming growth factor (TGF)B1, vascular endothelial growth factor (VEGF)A–C, placental growth factor (PIGF), and VEGF receptor (VEGFR)1–3 between the CCND1 amplification group and the neutral group in the TCGA pan-cancer cohort. Within each group, the scattered dots represent gene values, and the thick line represents the median value. The bottom and top of the boxes are the 25th and 75th percentiles. Differences between the two groups were determined by unpaired t-tests.