Figure 1.

Prenatal poly I:C treatment reduces excitatory synaptic inputs onto CA1 pyramidal cells in adulthood. (A) Representative data of spontaneous excitatory postsynaptic currents (sEPSCs) recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right). (B) Left: the frequency of sEPSCs of poly I:C-treated mice showed a trend to be significantly lower than that of PBS-treated mice. Right: Cumulative probability of sEPSC frequencies shows a right-skewed curve in poly I:C-treated mice compared to that in PBS-treated mice. (C) Left: the amplitude of sEPSCs of poly I:C-treated mice was significantly smaller than that of PBS-treated mice. Right: cumulative probability of sEPSC amplitudes shows a left-skewed curve in poly I:C-treated mice compared to that in PBS-treated mice. (D) Representative data of miniature excitatory postsynaptic currents (mEPSCs) recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right). (E) Left: the frequency of mEPSCs in poly I:C-treated mice was significantly lower than that in PBS-treated mice. Right: cumulative probability of mEPSC frequencies shows a right-skewed curve in poly I:C-treated mice compared to that in PBS-treated mice. (F) Left: there was no significant difference in mEPSC amplitude between PBS-treated and poly I:C-treated mice. Right: overlapping cumulative probability curve between PBS-treated and poly I:C-treated mice, *p < 0.05, **p < 0.01. Data are presented as means, and error bars indicate SEM. Poly I:C, polyriboinosinic-polyribocytidilic acid; PBS, phosphate-buffered saline.