Figure 3.

In the early postnatal period, prenatal poly I:C treatment partially affects excitatory drive onto CA1 pyramidal cells. (A) Representative data of sEPSCs recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right) in each PD during the neonatal period. (B) There was a significant difference in sEPSC frequency between PBS-treated and poly I:C-treated mice. (C) There was no significant difference in sEPSC amplitude between PBS-treated and poly I:C mice. (D) Representative data of mEPSCs recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right) in each PD during the neonatal period. (E,F) There were no significant differences in mEPSC frequency and amplitude between PBS-treated and poly I:C-treated mice, *p < 0.05. Data are presented as means, and error bars indicate SEM. Poly I:C, polyriboinosinic-polyribocytidilic acid; PBS, phosphate-buffered saline; sEPSC, spontaneous excitatory postsynaptic current; mEPSC, miniature excitatory postsynaptic current.