Figure 4.

The impact on GABAergic drive and synaptic inputs onto CA1 pyramidal cells in the early postnatal period by prenatal poly I:C treatment are undetected. (A) Representative data of sGABA_A-PSCs recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right) in each PD during the neonatal period. (B,C) There were no significant differences in sGABA_A-PSC frequency and amplitude between PBS-treated and poly I:C-treated mice. (D) Representative data of mGABA_A-PSCs recorded from a CA1 pyramidal cell of a PBS-treated mouse (left) and poly I:C-treated mouse (right) in each PD during the neonatal period. (E,F) There were no significant differences in mGABA_A-PSCs frequency and amplitude between PBS-treated and poly I:C-treated mice. Poly I:C, polyriboinosinic-polyribocytidilic acid; PBS, phosphate-buffered saline; mGABA_A-PSC, miniature GABA_A receptor-mediated postsynaptic current; sGABA_A-PSC, spontaneous GABA_A receptor-mediated postsynaptic current.