Table 1.
Membrane properties of pyramidal cells from offspring of PBS-treated and poly I:C-treated dams.
| Postnatal day | PBS (n) | Poly I:C (n) | ||
|---|---|---|---|---|
| Action potential threshold (mV) | 0–4 | −36.87 ± 1.53 (10) | −42.00 ± 1.54 (9) | F(1.49) = 6.00 |
| P < 0.05a | ||||
| 5–9 | −43.61 ± 0.94 (8) | −46.14 ± 1.04 (10) | ||
| 10–15 | −48.61 ± 1.16 (10) | −48.81 ± 1.41 (8) | ||
| adult | −50.08 ± 1.15 (12) | −49.28 ± 0.94 (16) | nsb | |
| Action potential amplitude (mV) | 0–4 | 50.95 ± 4.19 (10) | 55.22 ± 5.82 (9) | nsa |
| 5–9 | 78.95 ± 3.04 (8) | 81.19 ± 3.49 (10) | ||
| 10–15 | 92.75 ± 1.33 (10) | 91.35 ± 2.04 (8) | ||
| adult | 92.93 ± 2.42 (12) | 91.91 ± 1.69 (16) | nsb | |
| Afterhyperpolarization amplitude (mV) | 0–4 | −17.25 ± 1.43 (10) | −17.27 ± 2.00 (9) | nsa |
| 5–9 | −17.86 ± 1.76 (8) | −15.47 ± 0.98 (10) | ||
| 10–15 | −10.62 ± 1.06 (10) | −10.76 ± 1.30 (8) | ||
| adult | −11.21 ± 0.80 (12) | −10.70 ± 0.66 (16) | nsb |
Values reflect means and standard errors, n: numbers of neurons, ns: statistically non-significant. Statistics, atwo-way ANOVA, bStudent t-test. The action potential threshold of poly I:C-treated group was lower than that of PBS treated-group in the neonatal period, but not in adulthood. There was no significant difference in action potential amplitude and afterhyperpolarization amplitude in any developmental period between PBS-treated and poly I:C-treated groups.