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PD-1 and TIGIT combination blockade increases the function of NK and T cell in MDS patients. (A) TIGIT and PD-1 blockade increases the secretion of CD107a, TNF-a, and IFN-y in NK, CD8+T, and CD4+T from MDS. (B) TIGIT+ and TIGIT– T from NK and T cells co-cultured with CD155 of BM. Data are presented as mean ± SD. Statistical significance was determined by non-parametric one-way ANOVA followed by Dunn’s multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.0001.
