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TIGIT, PD-1, and CD226 in T and NK cell mediate the immune response. Increased expression of TIGIT and PD-1 in NK and T cell induces excessive negative regulation, leading to decreased anti-tumor function. Although CD226 can enhance the anti-tumor effect of NK and T cell, its binding power with CD155 is low, and TIGIT can inhibit the binding of CD226 with CD155.
