TABLE 3A.
Cox regression analysis stratified for level of consciousness showing Hazard Ratios (HR) for 90-day mortality in 337 patients with VKA-ICH.
| Variable | HR | 95% CI | P-value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Crude model (non-stratified) | ||||
| No VKA reversal | 2.20 | 1.54 | 3.13 | <0.001 |
| Adjusted model (stratified)* | ||||
| No VKA reversal | 1.49 | 0.94 | 2.37 | 0.09 |
| Male sex | 1.42 | 0.93 | 2.16 | 0.10 |
| Age | 1.06 | 1.03 | 1.09 | <0.001 |
| Diabetes | 1.68 | 1.01 | 2.79 | 0.05 |
| Hypertension | 0.68 | 0.44 | 1.06 | 0.09 |
| Atrial fibrillation | 0.53 | 0.28 | 1.01 | 0.05 |
| Pre-stroke dependency | 0.79 | 0.50 | 1.25 | 0.31 |
| INR | ||||
| < 1.7 | 1 | |||
| 1.7–3 | 1.96 | 0.69 | 5.54 | 0.21 |
| >3 | 2.16 | 0.75 | 6.25 | 0.15 |
| Intraventricular hemorrhage | 2.23 | 1.45 | 3.43 | <0.001 |
| Neurosurgery not performed | 2.38 | 0.80 | 7.12 | 0.12 |
| Infratentorial hemorrhage | 1.37 | 0.78 | 2.39 | 0.28 |
Simple analysis is displayed as a crude model. ICH, intracerebral hemorrhage; CI, confidence interval; VKA, vitamin K antagonist; INR, international normalized ratio.
*
Stratified for level of consciousness (alert, drowsy, and comatose).