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. 2020 Jul 30;8:678. doi: 10.3389/fcell.2020.00678

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Copyright © 2020 Domingues, Geraldo, Anjo, Matos, Almeida, Caramelo, Lopes-da-Silva, Paiva, Carvalho, Pires das Neves, Manadas and Grãos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematics illustrating the modulation of Cofilin-1 by substrates stiffness or soluble factors affecting intracellular contractility. Stiff substrates or actomyosin tension induced by LPA favour elevated levels of F-actin, Cofilin-1 phosphorylation and Cofilin-1 adopts a mainly cytosolic localisation. On the other hand, soft substrates or low actomyosin tension caused by treatment with Blebbistatin induce low amounts of F-actin, no Cofilin-1 phosphorylation and Cofilin-1 adopts a nuclear localisation. The presence of Cofilin-1 in the nucleus is consistent with enhanced/faster RNA polymerase II-dependent transcription.