Table 3.
Glucocorticoid type and hydrocortisone equivalent dose of patients with congenital adrenal hyperplasia in the included studies.
| First author and year | Type of glucocorticoids used for treatment and number of patients on each type | Averagea daily hydrocortisone equivalent dose (mg/m2/day) | Comments |
|---|---|---|---|
| Ceccato 2016 (42) | Prednisolone, n = 1 Hydrocortisone, n = 3 Dexamethasone, n = 34 |
10+/−5 | Cumulative glucocorticoid dose was not related to bone metabolism or BMD. |
| Falhammar 2007 (36) | Prednisolone, n = 30 Hydrocortisone, n = 17 Cortisone, n = 5 Dexamethasone, n = 7 Combination of two, n = 2 |
16.9+/−0.9 | No correlations were found between BMD and the current glucocorticoid dose. |
| Falhammar 2013 (37) | Prednisolone, n = 18 Hydrocortisone/Cortisone, n = 8 |
17.4+/−5.2 | No correlations were found between BMD and the current glucocorticoid dose. Patients on prednisolone had lower BMD than those on hydrocortisone/cortisone. |
| Guo 1996 (23) | Prednisolone, n = 2 Hydrocortisone, n = 3 Cortisone, n = 1 Dexamethasone, n = 5 |
17.4 | The total glucocorticoid dose in the previous 2 years was not correlated with BMD |
| Hagenfeldt 2000 (33) | Prednisolone, n = 5 Cortisone, n = 1 Dexamethasone, n = 5 Triamcinolone, n = 1 Cortisone+Pred, n = 1 |
17.5 | Negative correlation was found between BMD and the calculated index of accumulated post-menarcheal glucocorticoid dose |
| King 2006 (35) | Prednisone, n = 13 Cortisol, n = 10 Dexamethasone, n = 3 |
SW CAH: 22 (8–38) SV CAH: 17 (11–46) LS T-score < −1: 22 (13–28) LS T-score > −1: 15 (8–46) |
There were not higher cortisol equivalents per body surface area among the osteopenic CAH patients compared to CAH patients with normal BMD |
| Raizada 2016 (43) | Prednisolone, n = 1 Dexamethasone, n = 14 (Pred+Dex, n = 6 Hydrocortisone+Dex, n = 5) |
NR | Steroid doses not reported due to missing records |
| Sciannamblo 2006 (34) | Hydrocortisone (NR) Dexamethasone (NR) |
F:15.3+/−1 M:17.1+/−1.1 | No correlations were found between BMD and current glucocorticoid dose, nor the mean dose of the previous 7 yrs |
| Stikkelbroeck 2003 (25) | NR | F: 9.66+/−2.83 M: 13.16+/−2.66 | No significant correlations were found between cumulative glucocorticoid doses in the last 0.5, 2, or 5 yr and bone parameters. |
NR, not reported; BMD, bone mineral density.
a
average presented as mean+/- standard deviation or mean+/- standard error of mean or median(range).